Gene Expression Regulation Database

Gene Expression Regulation Database (GREDB) has been developed to facilitate systems-level analyses that will provide insights into the question of how genes are regulated that governing a specific biological response. GREDB is a publicly available, manually curated biological database depositing the human gene expression regulation relationships (Links). To date, more than 39,000 Links have been contextual-ly annotated through the review of 53,000 plus abstracts. GREDB has the ability to analyze user-supplied gene expression data using the GEREA bioinformatics tool in a causal analysis oriented manner.

The database can be searched use NCBI official gene symbol (eg. CDC42).


The flat file format of the rational database in the back end is able to download and analyzed locally using the GEREA bioinformatics tool or GRERA-web online.

The new version of GereDB is online for testing, please visit the following link: Run New GereDB online.

Please cite the following publication:

Huang, Tinghua & Huang, Xiali & Shi, Bomei & Yao, Min. (2019). GEREDB: Gene Expression Regulation Database Curated by Mining Abstracts From Literature. Journal of Bioinformatics and Computational Biology. 10.1142/S0219720019500240.

The database was developed by Tinghua Huang's group at Yangtze University.